Compared to mice, rabbits offer benefits when it comes to developing rabbit antibodies. The obvious reason is the difference in size. One rabbit spleen contains comparatively more B cells than what can be gained from one mouse spleen. More B cells that develop antibodies means a higher chance of finding the exact clone needed for expansion.
Antibodies Against a Wider Range of Epitopes
Rabbits’ immunoglobulin genes are capable of developing antibodies that fit an extensive range of epitopes, more than mouse antibodies. Isoforms of a protein can separate by one amino acid residue, which results in a small difference in structure. A rabbit’s immune response can form antibodies that are better able to encounter these subtle differences.

Small Molecules are More Immunogenic in Rabbits Than Mice
A rabbit’s immune system is ideal for mounting an immunogenic response to tiny molecules that are even not very immunogenic to mice. For instance, small molecules with a small epitope injected into a rabbit have more chances to have higher titers than a mouse (as the rabbits have more intricate immune response to antigens).

Reduced Immunodominance
When definite epitopes from the same antigen are more immunogenic than others, it is called immunodominance. This impacts the immune system that is producing antibodies. Rabbits have lower immunodominance than mice.
The combination of these advantages results in a wider range of antibodies and therefore greater chance of finding the right experimental tools than with traditional technologies. If you are looking for rabbit antibodies, Capralogics Inc. is your place. We utilize technology that enables the development of high-specificity, high-affinity rabbit antibodies like rabbit anti-llama Alkaline Phosphatase for many challenging targets.
At Capralogics Inc., we are a full-service polyclonal antibody development facility. We have been dedicated to providing high-quality antibodies to the diagnostic, research, and pharmaceutical industries for more than 25 years. Not only do we provide high quality animal plasma and serum, but we also manufacture and offer novel research antibody products at great prices. For additional queries, writes us at [email protected].

Contact Us:

Capralogics, Inc.
356, Hardwick, MA 01037 USA
Mob.No: (800) 975-6866 • (413) 477-6866
Fax: (413) 643-0067
Website: https://www.capralogics.com/