Microscopic Polyangiitis Market Regional Analysis

Europe Microscopic Polyangiitis Market is expected to witness significant growth over the forecast period, owing to proposed product launches. For instance, Bristol-Myers Squibb Company is conducting phase lll clinical trials for Abatacept (Orencia), which is expected to be completed by September 2022. Orencia is a recombinant protein, which inhibits the T lymphocyte activation pathway, thereby suppressing the immune system.

Microscopic polyangiitis (MPA) occurs due to inflammation of blood vessels resulting in damage to other organs, mostly kidney, lungs, nerves, skin, and joints. MPA is an immune system mediated disorder, however the exact reason leading to immune system dysfunction is unknown. Since MPA affects multiple organs, various symptoms such as illness, fatigue, fever, loss of weight and appetite, coughing blood in case of lungs, and loss of sensation in case of nerves can be seen. Diagnosis involves blood test for antineutrophil cytoplasmic antibodies (ANCA), urine test for detection of red blood cells (RBCs), and imaging techniques such as computed tomography (CT), magnetic resonance (MR) scan, and X-rays. If results of these tests are positive for presence of MPA, biopsy (tissue sample testing) is performed for confirmation of presence of MPA.

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Microscopic Polyangiitis Market Drivers

In the recent past, various regulatory bodies such as European Medicines Agency (EMA), the U.S. Food and Drug Administration (FDA), Medicines and Healthcare products Regulatory Agency (MHRA), and others have granted treatment related approvals. Such treatment approvals are expected to propel the global microscopic polyangiitis market growth over the forecast period. For instance, in October 2018, Genentech, Inc., a San Francisco-based biotechnology company, received approval from the U.S. Food and Drug Administration (FDA) to update the Rituxan label to include the follow-up treatment information of adult patients suffering from granulomatosis with polyangiitis and microscopic polyangiitis, who had shown improvement in medical condition with the glucocorticoid and cyclophosphamide induction treatment.

Launch of new treatment methods by key players is expected to drive the global microscopic polyangiitis market growth over the forecast period. For instance, in July 2018, InflaRx N.V., a German clinical stage bio-pharmaceutical company, received an approval from the U.S. Food and Drug Administration (FDA) for conducting phase-2 clinical trials to assess the safety and effectiveness of IFX-1 for treatment of anti-neutrophil cytoplasmic autoantibody (ANCA) vasculitis, presence of which indicates that the patient is suffering from microscopic polyangiitis. IFX-1 is an inhibitor of the complement system (a component of immune system) and neutralizes C5a component without affecting the normal immune functions. These factors are expected to drive the global microscopic polyangiitis market growth over the forecast period.

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Microscopic Polyangiitis Market Restraints

The corticosteroids have side effects, which include skin thinning and intense pain. The monoclonal antibody production involves costly and time consuming research. Azathioprine involves side effects such as diarrhea, joint pain, loss of coordination, seizure, and vision changes. These factors are expected to restrain the global microscopic polyangiitis market growth over the forecast period.

In March 2018, Amerigen Pharmaceuticals Limited, a China-based generic pharmaceutical company, was granted approval for its Abbreviated New Drug Application (‘ANDA’), by the U.S. FDA, for its cyclophosphamide capsules 25mg and 50mg. Cyclophosphamide is an immunosuppressive agent used for the treatment of microscopic polyangiitis in combination with corticosteroids. This is expected to propel the Asia Pacific microscopic polyangiitis market growth over the forecast period in turn supporting global microscopic polyangiitis market growth.

Microscopic Polyangiitis Market Key Players

Some of the key players operating in the global microscopic polyangiitis market include Genentech, Inc., Celltrion, Inc., InflaRx N.V., ChemoCentryx Inc., Bristol-Myers Squibb Company, Teijin Pharma Ltd, Amerigen Pharmaceuticals Limited, Sandoz International GmbH (Novartis Division), and TTY Biopharm Company Ltd.

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