In SituHybridization Market Size And Forecast
InSitu Hybridization Market size was valued at USD 656.60 Million in 2019 and isprojected to reach USD 995.61 Million by 2027, growing at a CAGR of 5.76% from 2020 to2027.

Globally,raising awareness of the use of in situ hybridization, growing healthcareexpenditure levels, increasing prevalence of cancer, and growing usage inresearch activities & laboratories to diagnose cancer, chromosomalabnormalities and infectious diseases are the prime growth drivers of theglobal In Situ Hybridization Market. The Global In Situ Hybridization Marketreport provides a holistic evaluation of the market. The report offers acomprehensive analysis of key segments, trends, drivers, restraints,competitive landscape, and factors that are playing a substantial role in themarket.

GlobalIn Situ Hybridization Market Definition
In-situhybridization utilizes a labeled probe of complementary RNA, DNA, or modifiednucleic acid to localize particular DNA or RNA sequences in the smallcross-section of tissues or an entire tissue. In addition, in-situhybridization indicates the localization of gene expression in their cellularenvironment. In situ hybridization is a technique that helps in the preciselocalization of a particular segment of nucleic acid in a histologic section.

TheDNA or RNA probe is used in detecting complementary genetic material in tissuesor cells. The two types of in situ hybridization namely fluorescence in situhybridization (FISH), and chromogenic in situ hybridization (CISH) are used toidentify the position of genes, which offer useful insights regarding tumors.The hybridization technique is used frequently for the location of specificnucleic acid sequences on chromosomes or in tissues for understanding theorganization, regulation, and function of genes. The in-situ hybridizationtechnique expands the capabilities to satisfy any therapy needs and enable newdiagnostic, treatment applications for patients suffering from cancer or otherchronic diseases.

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Itsunique technology in the rapid detection of aneuploidies during the prenatalstage ensures the better functional ability for detecting abnormalities relatedto birth defects or mental disorders. In situ hybridization is specificallyuseful in neuroscience. In situ hybridization has wide applications inmicrobiology, pathology, developmental biology, karyotyping & phylogeneticanalysis, and physical mapping. However, the inability of probes to detecttargeted sequences after few repeats can lead to the use of insufficient probesin few regions. This is likely to restrain the growth of in situ hybridizationtechniques in laboratories.

GlobalIn Situ Hybridization Market Overview
Themajor drivers that fuel the growth of the market are an increase in cancerprevalence, a rise in awareness about cancer along with technology advancementsin cancer therapeutics, and an increase in government initiatives. Risingawareness of the use of in situ hybridizations, growing healthcare expenditurelevels, and growing usage in research activities & laboratories to diagnosecancer, chromosomal abnormalities, and infectious diseases are the prime growthdrivers of the global In Situ Hybridization Market.

Highprevalence of diseases such as cancer, Alzheimer’s disease, and other chronicdiseases, rise in patient awareness, the surge in pharmacodynamics studies, andincrease in diagnostic centers for treatment procedures drive the global InSitu Hybridization Market. An article published in 2014 stated that scientistsare profiling T-cell activation using in situ hybridization technique and flowcytometry which will help to detect the culturing technique of pathogens andtheir amplification methods. These initiatives by associations and governmentfunding is also likely to propel the hybridization technique in the nearfuture. The number of new cancer cases is likely to rise to 22 million withinthe next two decades. Incidence of cancer can be reduced through earlydetection of disease and management of patients who develop symptoms related tothe disease. An increase in the number of patients with cancer and differenttypes of chronic diseases and rapidly rising awareness about detectiontechniques are projected to fuel the growth of the In Situ HybridizationMarket.

Furthermore,the development of technologies to create high-value in-situ hybridization andincrease in adoption of in-situ hybridization in emerging economies such asChina, India, and others, will create new opportunities for the global In SituHybridization Market. However, the high cost of probes, low detection abilityof FISH (fluorescence in situ hybridization) for major abnormalities ofpatients, and significant time is taken by the detection procedures areexpected to hamper the In Situ Hybridization Market. Moreover, the availabilityof better technologies, such as high-throughput whole genome sequencing andmicroarray, and others restrain the growth of the global In Situ HybridizationMarket.

GlobalIn Situ Hybridization Market: Segmentation Analysis
TheGlobal In Situ Hybridization Market is Segmented on the basis of Technology,Application, End-User, And Geography.

InSitu Hybridization Market, By Technology
•Fluorescence In Situ Hybridization Market (FISH)
o DNA-FISH
o RNA-FISH
• Chromogenic In Situ Hybridization Market (CISH)

Basedon Technology, the market is bifurcated into Fluorescence In Situ HybridizationMarket (FISH), and Chromogenic In Situ Hybridization Market (CISH). Chromogenicin situ hybridization is a rapidly expanding segment owing to the increase inthe use of techniques in diagnostic laboratories globally.

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InSitu Hybridization Market, By Application
•Cancer Diagnosis
• Immunology
• Neuroscience
• Cytology
• Infectious Diseases

Basedon Application, the market is bifurcated into Cancer Diagnosis, Immunology,Neuroscience, Cytology, and Infectious Diseases. The cancer diagnostics segmentaccounted for the largest share of the global market. This can be attributed tothe high demand for FISH in the detection of cellular and genetic markers incancers such as HER2, ALK, and ROS.

InSitu Hybridization Market, By End-User
•Molecular Diagnostic Laboratories
• Pharmaceutical & Biotechnology Companies
• Contract Research Organizations (CROS)
• Academic & Research Institutions

Basedon End-User, the market is bifurcated into Molecular Diagnostic Laboratories,Pharmaceutical & Biotechnology Companies, Contract Research Organizations(CROS), and Academic & Research Institutions. Diagnostic laboratories areincreasing their revenue due to the increase in the number of diagnoses ofinfectious diseases following the environmental changes, and the rise in theprenatal test for disease identification. These factors are likely to drive thesegment during the forecast period.

InSitu Hybridization Market, By Geography
•North America
• Europe
• Asia Pacific
• Rest of the world

Basedon regional analysis, the Global In Situ Hybridization Market is classifiedinto North America, Europe, Asia Pacific, and the Rest of the world. NorthAmerica accounted for the largest share of the In Situ Hybridization Market dueto an increase in funding for the development of research and health careinfrastructure and a rise in biomedical research activities. The increasingincidence of cancer and infectious diseases in the region is driving the focuson the development of personalized medicine and diagnostics tests in the U.S.As a result, due to the strong demand for early cancer detection capabilities,the market for ISH-based diagnostic tests is expected to see steady growth.

Europeis the second-largest market for in situ hybridization due to favorablegovernment policies regarding the development of health care infrastructure andmolecular diagnostic companies engaged in hybridization techniques. The marketin the Asia Pacific is expected to expand at a high growth rate during theforecast period due to an increase in cancer prevalence and diagnosis, changinglifestyle, rise in awareness among patients, and surge in per capita expenditure.Additionally, economic growth in India, China, and the Philippines supports thehealth care infrastructure as well as the expansion of biotechnology companiesand pharma labs. This is expected to fuel the growth of the market in the AsiaPacific.

KeyPlayers
The“Global In Situ Hybridization Market” study report will provide valuableinsight with an emphasis on the global market. The major players in the marketare ABBottLaboratories, Inc., F.Hoffmann-La Roche Ltd., Thermofisher Scientific, Inc.,Merck KGaA, Agilent Technologies, Inc., Perkin Elmer, Inc., Danaher Corporation/ Leica Biosystems Nussloch GmbH, Exiqon A/S, Biogenex Laboratories, Inc.,Advanced Cell Diagnostics, Inc, Bio Sb, Inc.

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