Manidipine Hydrochloride Market Size And Forecast

Manidipine Hydrochloride Market size is growing at a moderate pace with substantial growth rates over the last few years and is estimated that the market will grow significantly in the forecasted period i.e. 2021 to 2028.

With growing incidences of renal impairment and hypertension, the demand for manidipine hydrochloride is increasing which acts as the key growth driver of the Manidipine Hydrochloride Market. The Global Manidipine Hydrochloride Market report provides a holistic evaluation of the market. The report offers a comprehensive analysis of key segments, trends, drivers, restraints, competitive landscape, and factors that are playing a substantial role in the market.

Global Manidipine Hydrochloride Market Definition

Hypertension is a prime fallout of renal impairment. Manidipine hydrochloride is an anti-hypertensive agent administered orally to patients suffering from hypertension and renal impairment. It is a calcium channel antagonist that blocks the calcium channel, therefore inducing vasodilation, and reducing systolic blood pressure and diastolic blood pressure. Manidipine has a long-lasting stay and therefore its dose is required once a day in the market, it is available in powdered and capsule form.

Furthermore, Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of acuteness for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardio depression. In addition, manidipine does not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation.

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It has a gradual onset of action and a long duration of action enabling once-daily administration. Moreover, manidipine dilates both the efferent and the afferent renal arterioles and appears to have beneficial renal effects unrelated to its antihypertensive effect. Once-daily oral manidipine is an effective and generally well-tolerated antihypertensive agent for younger and elderly adult patients with mild-to-moderate hypertension.

Besides, in a large double-blind trial, the incidence of ankle edema was remarkably lower in manidipine than in amlodipine recipients. Therefore, Manidipine is also adequate in hypertensive patients with comorbidities, such as type 2 diabetes mellitus or renal impairment, and appears to improve insulin sensitivity without affecting metabolic function. Consequently, Manidipine illustrates a first-line treatment option for patients with crucial mild-to-moderate hypertension.

Global Manidipine Hydrochloride Market Overview

Manidipine is a dihydropyridine class calcium channel blocker (CCB) that exerts its antihypertensive activity via targeting both L-type and T-type calcium channels. Therefore, Manidipine diminishes glomerular pressure and, consequently, albumin excretion via its action against T-type channels of efferent arterioles in addition to promoting afferent arteriole dilation by blocking L-type channels. Clinically, Manidipine is as effective in lowering blood pressure as other dihydropyridines, while only Manidipine significantly reduces albuminuria and insulin resistance with fewer adverse effects.

Furthermore, with the growing incidences of renal impairment and hypertension, the demand for manidipine hydrochloride is increasing which acts as the key growth driver of the Manidipine Hydrochloride Market. A change in lifestyle habits has increased the number of patients suffering from hypertension. A growing prevalence of hypertension and hypertension-related renal failure is likely to increase the demand and market to propel.

However, it comes with several side effects including ankle edema, palpitation, headache, dizziness, flushing, and fatigue which act as the major restrain and diminish the growth of the Manidipine Hydrochloride Market. Also, with the growing awareness about health, people have started adopting a healthy and active life to prevent hypertension, which has slowed down the usage of these types of medicines.

Global Manidipine Hydrochloride Market: Segmentation Analysis

The Global Manidipine Hydrochloride Market is Segmented on the basis of Form, Application, And Geography.

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Manidipine Hydrochloride Market, By Form

• Powder
• Capsule

Based on Form, The market is segmented into Powder and Capsule. The Powder segment holds the big market share. Manidipine dihydrochloride is a small molecule that can act as an L-type calcium channel blocker. It is provided as a powder.

Manidipine Hydrochloride Market, By Application

• Hypertension
• Renal Impairment
• Others

Based on Application, The market is segmented into Hypertension, Renal Impairment, and Others. The Hypertension segment holds the big market share. Moreover, Manidipine is indicated for the treatment of mild to moderate essential hypertension (high blood pressure). Manidipine works by relaxing blood vessels, so that blood pressure is reduced.

Manidipine Hydrochloride Market, By Geography

• North America
• Europe
• Asia Pacific
• Rest of the world

On the basis of Geography, The Global Manidipine Hydrochloride Market is classified into North America, Europe, Asia Pacific, and the Rest of the world. The Europe region is expected to witness the highest CAGR during the forecast period. This is majorly due to the growing prevalence of lifestyle disorders such as cardiovascular disease, diabetes, etc. primarily drives the Manidipine Hydrochloride Market growth in the region.

Key Players

The “Global Manidipine Hydrochloride Market” study report will provide a valuable insight with an emphasis on the global market including some of the major players such as EIL Pharmaceutical, Manus Aktteva Biopharma, Toronto Research Chemicals, Watanable Chemical Co Ltd, Xian Sonwu Biotech Co Ltd, Hefei Joye Import and Export Co Ltd., Shandong Octagon Chemicals Limited, Triquim, ATK Chemical Company Ltd, BOC Science and among others.

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