The research community and the biopharmaceutical industry have mobilized with unprecedented speed against the COVID-19 pandemic. Hence, organ-on-chip is founded to be one of the most promising and go-to technology during the development of vaccines and drugs that have been currently under clinical studies for the treatment of the infection. For instance, in March 2020, as a part of the World Health Organization’s (WHO) Research and Development Blueprint response to the COVID-19 outbreak, the Emulate Lung-Chip was used to provide preclinical insights into the efficacy of hydroxychloroquine for COVID-19.

An organ-on-a-chip is a microfluidic cell culture device that contains continuously perfused chambers. This chip develops a narrow channel for the blood and airflow in organs, such as the lung, gut, liver, heart, and other organs. Such devices produce multiple levels of tissue and organ functionalities, which are not feasible using conventional 2D and 3D culture systems. It offers a wide range of applications, such as disease modeling, patient stratification, and phenotypic screening.

The organ-on-chip market is driven by factors, such as a requirement for alternatives for animal testing, the need for early detection of drug toxicity, and new product launches and advancements in technology that are also responsible for driving the market. For instance, in December 2020, CN Bio and the University of Melbourne collaborated to advance therapies through the lung-on-a-chip technology for respiratory complications among patients who have recovered from COVID-19.

In addition, in October 2020, BioVox raised awareness through an initiative to promote the organ-on-chip technology for improvisation in vitro research models and for reducing animal testing.

The demand for personalized medication and the vast applications of organ-on-chip beyond the pharmaceutical industry are the major factors creating growth opportunities for market players. However, complexity of organ-on-chip models may hindered the market gropwth over forecast period.

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Key Market Trends

Lung-related Application is Expected to Exhibit the Good Growth Rate Over the Forecast Period

The recent global COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2, necessitates rapid advances in research and development activities for different approaches to treating the infection. For instance, in April 2020, researchers at the Wyss Institute demonstrated that human airway organ chips can be used to model COVID-19 and the immune response toward the same, in order to test the effectiveness of drugs to curb the infection.

The development of new solutions to treat pulmonary diseases is currently of primary importance, as pulmonary diseases are found to be among the most dreadful conditions, globally.

According to the World Health Organization’s Global Tuberculosis Report 2020, there were an estimated 10.0 million new cases of TB disease (also known as active TB) in 2019. This is equivalent to 130 cases per 100,000 people, with an estimated 1.2 million deaths due to TB, globally.

The lung-on-chip technology is a complex, three-dimensional model of a living, breathing human lung on a microchip. This device, made up of human lung and blood vessel cells, can predict the absorption of airborne nanoparticles and mimic the inflammatory response triggered by microbial pathogens.

The device can also be used to test the effects of environmental toxins, absorption of aerosolized therapeutics, and the safety and efficacy of new drugs. It is expected to become an alternative to animal testing.

With the combination of the micro fabrication techniques with modern tissue engineering, lung-on-chip also offers a new in vitro approach to drug screening by mimicking the complicated mechanical and biochemical behaviors of a human lung.

In October 2019, the Biomedical Advanced Research and Development Authority (BARDA), a part of the US Department of Health and Human Services (HHS), announced its plans to provide technical expertise and approximately USD 13.5 million over the next two years to the Wake Forest Institute for Regenerative Medicine (WFIRM) of Winston-Salem, North Carolina, to validate how the group’s lung-on-chip technology, also known as an organ tissue equivalent, works in modeling the effects of chlorine gas on human lungs.

Hence, despite having already proven its worth, the lung-on-chip technology may also need to be engineered further, perhaps with muscle cells, to help test the effects of any treatment on the lungs, which may result in further growth of the market.

North America Captured the Largest Market Share and is Expected to Retain its Dominance Over Forecast Period

The COVID-19 pandemic accelerated the use of Organ-on-Chip usage for the development and testing of drugs. The market has witnessed various collaborations between research institutes and market players. For instance, in October 2020, the United States Food and Drug Administration has entered into a collaborative agreement to use lung-chips from Emulate, Inc. to evaluate the safety of COVID-19 vaccines and protective immunity against SARS-CoV-2.

Similarly, in October 2020, researchers at the U.S. Army Combat Capabilities Development Command (CCDC), Chemical Biological Center (CBC) has used Emulat’s Lung on Chip technology for research on COVID-19.

Currently, North America dominates the organ-on-chip market, owing to factors, such as the availability of a wide range of services offered by major players (which includes customized designing of new chips with specific organ arrangements) and an increase in toxicological testing of chemicals on the different types of organ cells. Huge investments are being made by the public and private institutes for their research.

For instance, several research institutions are actively involving in research and further advancing the technologies for Organ-on-Chip in the North America. For instance, in March 2020, Researchers at the Massachusetts Institute of Technology (MIT) have created a new model for organs-on-a-chip that could be a crucial step in developing treatments for inflammatory diseases and afflictions.

In September 2019, Javelin Biotech and Pfizer entered a three-year development of a platform to evaluate absorption, distribution, metabolism, and excretion (ADME) properties of small molecules on an organ-on-a-chip platform. The platform will help inform human pharmacokinetic (PK) predictions, which are often crucial measurements evaluating new drug candidates in preclinical research. This has further increased the growth in the market studied.

Competitive Landscape

The organ-on-chip market is highly competitive and consists of several major players. In terms of market share, few of the major players currently dominate the market. The presence of major market players, such as AxoSim Inc., BiomimX SRL, Elveflow, Emulate Inc., Hurel Corporation, InSphero AG, MIMETAS BV, Nortis Inc., Tara Biosystems Inc., and TissUse GmbH, is, in turn, increasing the overall competitive rivalry in the market. Product advancements and improvements in the organ-on-chip platforms by the major players are increasing the competitive rivalry.

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