Roots Analysis has done a detailed study on Cell Encapsulation: Focus on Therapeutics and Technologies, 2019-2030, covering key aspects of the industry’s evolution and identifying potential future growth opportunities.

Key Market Insights
• Presently, over 45 encapsulated cell therapies and encapsulation technologies are being evaluated across different phases of development by stakeholders across the world
• Ongoing therapy development programs are evaluating different types of cells, encapsulated in a wide range of biocompatible materials, aiming to offer viable and effective treatment options for various diseases
• In fact, majority of the product candidates are being developed for the treatment of metabolic disorders, primarily diabetes; big pharma are driving a significant proportion of research and development activity
• Clinical research in this field is growing at a fast pace; encapsulated therapy products are evaluating a number of pre-marketing end points to validate safety / efficacy
• Over the years, more than 3,000 patents have been granted / filed related to cell encapsulation technologies, demonstrating the heightened pace of research in this domain
• Foreseeing a lucrative future, several private and public investors have made capital investments worth approximately USD 1 billion, across over 100 funding instances, since 2013
• Growth in partnership activity reflects the rising interest of stakeholders in this domain; over 70% of deals have been inked related to therapies for metabolic disorders, involving both international and indigenous parties
• An evaluation of more than 300+ stakeholders engaged in cell therapies domain reveals the presence of several likely strategic partners spread across different geographical regions
• The short term opportunity in this market is likely to be driven by licensing activity and will depend on the untapped potential of novel cell encapsulation technologies in different application areas
• As multiple mid-late stage encapsulated cell therapies get commercialized in near future across different regions, the long term opportunity is likely to be distributed across diverse indications and encapsulation materials
• The enormous potential of encapsulated cell-based therapies / devices in the treatment of chronic disorders has captured the interest of several stakeholders in the industry

Table of Contents
1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines

2. EXECUTIVE SUMMARY

3. INTRODUCTION
3.1. Context and Background
3.2. An Overview of Cell Therapies
3.2.1. Cell Therapy Manufacturing
3.2.2. Supply Chain
3.2.3. Key Challenges
3.3. An Introduction to Cell Encapsulation
3.3.1. Historical Overview
3.3.2. Cell Encapsulation Approaches
3.3.3. Encapsulation Materials
3.3.4. Advantages and Challenges
3.4. Potential Applications of Cell Encapsulation
3.4.1. Targeted Drug / Therapy Delivery
3.4.2. Immunoprotection
3.4.3. Storage and Transportation
3.5. Key Growth Drivers and Road-blocks

4. CURRENT MARKET LANDSCAPE
4.1. Chapter Overview
4.2. Encapsulated Cell Therapies and Encapsulation Technologies: Developer Landscape
4.2.1. Distribution by Year of Establishment
4.2.2. Distribution by Geographical Location
4.2.3. Distribution by Size of Developers
4.2.4. Distribution by Type of Offering
4.3. Encapsulated Cell Therapies and Encapsulation Technologies: Development Pipeline
4.3.1. Distribution by Target Therapeutic Area
4.3.2. Distribution by Phase of Development
4.3.3. Distribution by Type of Cells and Other Encapsulated Components
4.3.4. Distribution by Type of Encapsulation Material Used
4.3.5. Distribution by Route of Administration
4.3.6. Distribution by Application Areas
4.4. Encapsulated Cell Therapies and Encapsulation Technologies: Initiatives of Big Pharmaceutical Players

5. ENCAPSULATED CELL THERAPIES AND ENCAPSULATION TECHNOLOGIES FOR METABOLIC DISORDERS: COMPANY PROFILES
5.1. Chapter Overview
5.2. Developers with Clinical Candidates
5.2.1. Beta-O2 Technologies
5.2.1.1. Company Overview
5.2.1.2. Financial Information
5.2.1.3. Product Description: ꞵAir Bio-artificial Pancreas
5.2.1.4. Recent Developments and Future Outlook
5.2.2. Diatranz Otsuka
5.2.2.1. Company Overview
5.2.2.2. Financial Information
5.2.2.3. Product Description: DIABECELL®
5.2.2.4. Recent Developments and Future Outlook
5.2.3. Sernova
5.2.3.1. Company Overview
5.2.3.2. Financial Information
5.2.3.3. Product Description: Cell Pouch System™
5.2.3.4. Recent Developments and Future Outlook
5.2.4. ViaCyte
5.2.4.1. Company Overview
5.2.4.2. Financial Information
5.2.4.3. Product Description: PEC-Direct™ and PEC-Encap™
5.2.4.4. Recent Developments and Future Outlook
5.3. Developers with Preclinical Candidates
5.3.1. ALTuCELL
5.3.2. Beta-Cell
5.3.3. Betalin Therapeutics
5.3.4. CellProtect Biotechnology
5.3.5. Defymed
5.3.6. Encellin
5.3.7. Kadimastem
5.3.8. PharmaCyte Biotech
5.3.9. Semma Therapeutics
5.3.10. Sigilon Therapeutics
5.3.11. Seraxis
5.3.12. SymbioCellTech

6. ENCAPSULATED CELL THERAPIES AND ENCAPSULATION TECHNOLOGIES FOR NON-METABOLIC DISORDERS: COMPANY PROFILES
6.1. Chapter Overview
6.2. Developers with Clinical Candidates
6.2.1. Azellon Cell Therapeutics
6.2.1.1. Company Overview
6.2.1.2. Financial Information
6.2.1.3. Product Description: Cell Bandage
6.2.1.4. Recent Developments and Future Outlook
6.2.2. EryDel
6.2.2.1. Company Overview
6.2.2.2. Financial Information
6.2.2.3. Product Description: EryDex System
6.2.2.4. Recent Developments and Future Outlook
6.2.3. Erytech Pharma
6.2.3.1. Company Overview
6.2.3.2. Financial Information
6.2.3.3. Product Description: GRASPA®
6.2.3.4. Recent Developments and Future Outloo
6.2.4. Gloriana Therapeutics
6.2.4.1. Company Overview
6.2.4.2. Financial Information
6.2.4.3. Product Description: EC-NGF
6.2.4.4. Recent Developments and Future Outlook
6.2.5. Living Cell Technologies
6.2.5.1. Company Overview
6.2.5.2. Financial Information
6.2.5.3. Product Description: NTCELL®
6.2.5.4. Recent Developments and Future Outlook
6.2.6. MaxiVAX
6.2.6.1. Company Overview
6.2.6.2. Financial Information
6.2.6.3. Product Description: MVX-ONCO-1
6.2.6.4. Recent Developments and Future Outlook
6.2.7. Neurotech Pharmaceuticals
6.2.7.1. Company Overview
6.2.7.2. Financial Information
6.2.7.3. Product Description: NT-501
6.2.7.4. Recent Developments and Future Outlook
6.2.8. PharmaCyte Biotech
6.2.8.1. Company Overview
6.2.8.2. Financial Information
6.2.8.3. Product Description: Cell-in-a-Box®
6.2.8.4. Recent Developments and Future Outlook
6.3. Developers with Preclinical Candidates
6.3.1. Beta-O2 Technologies
6.3.2. Sernova
6.3.3. Sigilon Therapeutics

7. PATENT ANALYSIS
7.1. Chapter Overview
7.2. Scope and Methodology
7.3. Encapsulated Cell Therapies and Encapsulation Technologies: Patent Analysis
7.3.1. Analysis by Publication Year
7.3.2. Analysis by Geographical Location
7.3.3. Analysis by CPC Classifications
7.3.4. Emerging Focus Areas
7.3.5. Leading Players: Analysis by Number of Patents
7.4. Encapsulated Cell Therapies and Encapsulation Technologies: Patent Benchmarking Analysis (Industry Players)
7.4.1. Analysis by Patent Characteristics
7.4.2. Analysis by Geographical Locatio
7.5. Encapsulated Cell Therapies and Encapsulation Technologies: Patent Valuation Analysis
7.6. Leading Patents: Analysis by Number of Citations

8. CLINICAL TRIAL ANALYSIS
8.1. Chapter Overview
8.2. Scope and Methodology
8.3. Encapsulated Cell Therapies and Encapsulation Technologies: List of Clinical Trials
8.3.1. Analysis by Trial Registration Year
8.3.2. Geographical Analysis by Number of Clinical Trials
8.3.3. Geographical Analysis by Enrolled Patient Population
8.3.4. Analysis by Phase of Development
8.3.5. Analysis by Study Design
8.3.6. Analysis by Type of Sponsor / Collaborator
8.3.7. Most Active Players: Analysis by Number of Registered Trials
8.3.8. Analysis by Trial Focus
8.3.9. Analysis by Therapeutic Area
8.3.10. Analysis by Clinical Endpoints

9. RECENT PARTNERSHIPS
9.1. Chapter Overview
9.2. Partnership Models
9.3. Encapsulated Cell Therapies and Encapsulation Technologies: Recent Collaborations and Partnerships
9.3.1. Analysis by Year of Partnership
9.3.2. Analysis by Type of Partnership
9.3.3. Analysis by Therapeutic Area
9.3.4. Analysis by Type of Cells and Other Encapsulated Components
9.3.5. Most Active Players: Analysis by Number of Partnerships
9.3.6. Analysis by Regions
9.3.6.1. Most Active Players
9.3.6.2. Intercontinental and Intracontinental Agreements

10. FUNDING AND INVESTMENT ANALYSIS
10.1. Chapter Overview
10.2. Types of Funding
10.3. Encapsulated Cell Therapies and Encapsulation Technologies: Recent Funding Instances
10.3.1. Analysis by Number of Funding Instances
10.3.2. Analysis by Amount Invested
10.3.3. Analysis by Type of Funding
10.3.4. Analysis by Number of Funding Instances and Amount Invested across Different Indications
10.3.5. Analysis by Amount Invested across Different Type of Cells and Other Encapsulated Components
10.3.6. Most Active Players: Analysis by Amount Invested
10.3.7. Most Active Investors: Analysis by Number of Instances
10.3.8. Geographical Analysis of Amount Invested
10.4. Concluding Remarks

11. GRANT ANALYSIS
11.1. Chapter Overview
11.2. Scope and Methodology
11.3. Encapsulated Cell Therapies and Encapsulation Technologies: List of Academic Grants
11.3.1. Analysis by Project Start Year
11.3.2. Analysis by Focus Area
11.3.3. Analysis by Support Period
11.3.4. Analysis by Type of Grant
11.3.5. Analysis by Amount Awarded
11.3.6. Analysis by Study Section
11.3.7. Analysis by Therapeutic Area
11.3.8. Analysis by Type of Cells and Other Encapsulated Components
11.3.9. Analysis by Type of Encapsulation Material
11.3.10. Leading Funding Institutes: Analysis by Number of Grants
11.3.11. Leading Recipient Organizations: Analysis by Number of Grants

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