The Global kifunensine market is expected to grow at a significant CAGR during the forecast period. Kifunensine is a mannosidase I inhibitor that is largely utilised in cell culture to produce high mannose glycoproteins. It stops the endoplasmic reticulum mannosidase I (ERM1) enzyme from trimming mannose residues from precursor glycoproteins inside the cell. Sarcoglycanopathies and lysosomal storage diseases have been treated by kifunensine. The European Commission approved the kifunensine orphan designation for the treatment of beta sarcoglycanopathy. The therapeutic potential of kifunensine is now being investigated in several diseases that benefit from its ability to inhibit mannosidase I.

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Kifunensine inhibited the formation of complex types of oligosaccharides by human skin fibroblasts or aortic endothelial cells at concentrations of 1 ug/ml or higher in the culture medium, resulting in the accumulation of (GlcNAc) oligosaccharides on cell surface N-linked glycoproteins, and more specifically on the scavenger-LDL receptor. Endoplasmic reticulum-associated degradation (ERAD) inhibits the natural folding of mutant lysosomal enzymes in a patient's fibroblasts in lysosomal storage diseases such as Gaucher's disease and Tay Sachs illness.

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Owing to its inhibitory effect, kifunensine is used in the growth of transformed mammalian cells to produce high mannose glycoproteins. It is faster to alter the glycosylation of a glycoprotein by combining a culture medium component with an already transformed cell line than it is to create a new cell line especially if a large number of cell lines or leads are being tested. Increasing the use of kifunensine for the cell culture produce glycoprotein and other diseases will drive the kifunensine market globally.

Global Kifunensine Market – Segmentation
By Type
Low Purity (Below 97%)
Purity (Above 97% and Below 99%)
High Purity (Above 99%)
Others
By Application
Cancer Treatment
Neurological Treatment
Endocrinological Treatment
Others

Global Kifunensine Market – Segmentation by Region 
North America 
United States
Canada
Europe
Germany
United Kingdom
France
Spain
Italy
Rest of Europe
Asia-Pacific 
China
Japan
India
Rest of Asia-Pacific
Rest of the World

Company Profiles
Glentham Life Sciences
R&D Systems
STEMCELL Technologies
Tocris Bioscience

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