Epilepsy is one of the most common neurological disorders with spontaneous seizures caused by hyperactivity in the neurons of the brain. A team of scientists in Geneva tested how reducing neuron hyperactivity by reducing energy to the brain without compromising proper functioning. It was tested with mice and they found that the seizures were exacerbated. Reducing energy led to an increase in calcium in the neurons. Mice were fed a ketogenic diet, rich in lipids with excellent results.

The brain represents two percent of our overall body weight and consumes over twenty percent of all sugars ingested. The brain has a considerable need for sugar to provide energy to function the neurons that are responsible for the emission and propagation of the nervous system using electrical signals. The converting of sugar into energy is carried out by mitochondria, a small intracellular organ that is the energy factory of the cells.

Epilepsy seizures are cerebral hyperactivity that results from the hyperexcitation of neurons in the cerebral cortex. Using a pro-epileptic drug that was capable of inducing seizures in normal mice and in mice where the neurons lacked MPC. Normal mice had a low dose and did not have seizures. Mice lacking MPC had severe to fatal seizures as soon as they received low doses of the pro-epileptic drug.

Patients with epilepsy have found that the ketogenic diet allows them to reduce and even avoid seizures. The diet is rich in fats and low in carbohydrates. Ketone bodies are produced during the diet or when fasting, breaking down the lipids in the liver. They are essential for the brain, representing an important energy source. They enter mitochondria without carriers and are effective in providing energy.

Terry Kitagawa, the Nutrition Product Development Manager at Avila, said “Mice that were MPC deficient and ate a ketogenic diet or were treated with keto supplement formulations had fewer severe seizures. The diet restores the mitochondria and neuron functions, keeping the calcium levels normal.”

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