Plasma fractionation is a process of separating various components of plasma, which in turn is a component of blood obtained through blood fractionation. Plasma is separated and can be used for many different medical applications. Plasma is taken from donors when whole blood is donated, or by plasmapheresis - a process by which the liquid part of the blood, or plasma, is separated from the blood cells and plasma is retained. This plasma can be used as Fresh Frozen Plasma (FFP) for replacement of clotting factors. Most plasma is used for products which derived from plasma fractionation. Plasma comprehends thousands of diverse proteins, but only about 20 of these are used to produce therapeutic plasma products. These fit into three classes’ immunoglobulins, clotting factors, and albumin.
Growth of this market is mainly attributed to increasing incidence of bleeding and immune disorders, growing geriatric population, and growing use of immunoglobulin and alpha-1-antitrypsin. Plasma fractionation is used for treating protein deficiency in healthcare applications and also as a packaging material for industrial applications. The prime function of plasma fractionation is removal or inactivation of viruses and prions.
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According to Centers of Disease Control (CDC) statistic, in 2012 chronic diseases were one of the major causes of death and disability in the U.S., with an estimated 117 million people suffering from some form of chronic disease. Developed diagnostic facilities, and comfort of access to healthcare along with increasing incidence and prevalence of chronic diseases all over the world, are some factors responsible for the rising demand for plasma derived products and is expected to drive the plasma fractionation market during the forecast period. The increase in geriatric population all over world is an important factor for plasma fractionation market, mainly due to the risk of complications of hemophilia, such as intracranial hemorrhage, inhibitor development, and joint diseases, increases along with the age of a person.

Key Developments:
• In September 2019, Biopharma, a Ukraine based company which is specialized for the production of plasma-based, recombinant and other drugs, launched a new plant for plasma fractionation in Bila Tserkva, Ukraine. The company offers a unique plasma fractionation technology which allows the plasma components of the blood to be processed for the extraction of life-saving drugs and the company is equipped with GMP – certified equipments and facilities. The launch of the company has put Ukraine almost on the same page as that of USA, Austria, and Germany. In the facility, production of blood products like Albumin, Bioven and Immunoglobulin is expected to help treat diseases caused due to immunodeficiency.
• In June 2019, Egypt initiated a project for the setup of the blood plasma fractionations and processing plant in the country in order to establish labs for the plasmapheresis.
Plasma Fractionation Market Taxonomy
By Product Type
• Albumin
• Immunoglobulins
• Coagulation Factor Concentrates
By Application
• Neurology
• Hematology
• Immunology
• Critical Care
By End User
• Hospitals
• Clinical Research Laboratories
By Region
• North America
• Latin America
• Europe
• Asia Pacific
• Middle East
• Africa
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Key players operating in the global plasma fractionation market are CSL Ltd., Octapharma AG, Grifols S.A, Baxalta Incorporated, Octapharma AG, and Kedrion S.p.A held the major share of the plasma fractionation market and will continue to take over the market. Other major players are Bio Products Laboratory, Sanquin, China Biologic Products, Inc., Biotest AG, and Laboratoire Français du Fractionnement et des Biotechnologies.

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