Nine types of conjugated drugs were reviewed from their characteristics, development progress and future development trend.

PROTAC is a heterobifunctional molecule with one end connected to a ligand that binds the target protein, one end to an E3 ubiquitin ligase, and a suitable Linker in the middle.

Currently, targeted protein degradators are mainly divided into two types: small molecular "molecular glue" and biffunctional molecular degradators (PROTAC).

PEG is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG has wide variety of applications depending on the length of the polymer chain and the molecular weight of the final polymer.

PEG linkers are widely used in biological and medical research, such as antibody-drug conjugates, nanoparticle drug delivery, biotinylation, PEGylation protein drugs and small molecule drugs, etc.

The nanoparticles, known as SNAs, house immune targets, globular DNA that can enter and stimulate immune cells with extremely high efficiency. SNAs have been tested in more than 60 cell types.

On February 16, 2022, the data on Paxlovid previously published by Pfizer and submitted to the FDA were published in the New England Journal of Medicine (NEJM).

Among adults with overweight or obesity, once-weekly subcutaneous semaglutide plus counseling for diet and physical activity results in significantly greater weight loss at 68 weeks than once-daily subcutaneous liraglutide.

Orlistat is a lipase inhibitor used in the treatment of obesity that works by inhibiting fat-metabolizing enzymes.

3D printing (3DP) technology has been repurposed to apply to pharmaceutical development, in recent years it has been used to produce tablets of personalized dosage and combine several prescriptions into one tablet.

Antibody-Drug Conjugates (ADC) is a type of anticancer drug that links a drug to cancer-targeting antibodies. The antibody detects tumor-specific proteins expressed on cancer cells and directs the cytotoxic anticancer drug towards the cancer cell.

Sacituzumab govitecan shows promise in treating the most aggressive type of breast cancer-metastatic triple-negative breast cancer.

These types of jabs are new but researchers have been working for decades to try to figure out how to use messenger RNA for other vaccinations and to treat illnesses from AIDS to cancer.

Several observational studies found a strong correlation between vitamin D deficiency and COVID-19.

Few days ago, the FDA amended the emergency use authorizations (EUAs) for both the Pfizer-BioNTech & the Moderna COVID-19 Vaccine to allow for the use of an additional dose in certain immunocompromised individuals.

The effectiveness of cancer treatment is influenced by a number of factors, such as the type and stage of cancer, the type of treatment, the characteristics of the cancer cells, and the lifestyle after treatment.

Monodispersed PEG linkers are pure compounds with a single molecular weight. In contrast, polydisperse PEGs linkers contain variations in molecular weight with an average molecular weight.

The Pfizer-BioNTech COVID-19 mRNA vaccine (Tozinameran or BNT162b2) is used to protect against COVID-19. This disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).