According to statistics from the World Health Organization (WHO), nearly 2 billion people are overweight or obese worldwide. Every year, overweight or obesity causes 2.8 million deaths.

What ‘s Orlistat ?

Orlistat is a lipase inhibitor used in the treatment of obesity that works by inhibiting fat-metabolizing enzymes. It was originally approved by the FDA in 1999 as the prescription drug Exenical, was approved in 2007 as the over-the-counter medication Alli. This drug is a generally well-tolerated and effective weight-loss aid.

What ‘s the mechanism of action?

Orlistat is a drug designed to treat obesity. It’sa potent and selective inhibitor of various lipase enzymes responsible for the metabolism of fat. It acts in the gastrointestinal (GI) tract via covalent binding to the serine residues located on the active site of both When orlistat is taken with food containing fat, it partially inhibits the enzymes of triglycerides. This decreases absorption of monoaclglycerides and free fatty acids, contributing to weight maintenance and weight loss.

What ‘s the side effects of the Orlistat ?

The main side effects of this drug are related to the gastrointestinal tract.
Abdominal pain or discomfort:
Oily discharge from the anus
Gas with oily anal discharge
Oily stools
More-frequent bowel movements
Urgent or hard-to-control bowel movements

Other possible side effects include:
Headache
Back pain
Upper respiratory infection

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